OUR SCIENCE
We believe that a viable treatment to the aging-associated neurodegenerative diseases should address the underlying aging processes, apart from targeting disease-specific pathological features. To achieve this goal, Memora Sciences leverages the breakthrough research of the founders. Our science anchor around (1) cracking the aging and immunological hurdles to provide better therapeutics; (2) enhancing brain-targeting drug delivery through a shuttling vector.
Key publications from the founding team:
1. Huang J, Kwok AJ, Li JCY, Chiu CLH, Ip BY, Tung LY, Zheng X, Chow HT, Lo MPS, Li Z, Chan RCC, Lin N, Wang Z, Wang M, Yan LYC, Chan DCW, Wu WKK, Chow KHM, Lin WJ, Tang Y, Ng BWL, Wong SH, Leung TW, Mok VCT, Ko H. "Functional and multi-omic aging rejuvenation with GLP-1R agonism", Under peer review, (full manuscript available as preprint)
2. Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H, "Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain", Nature Communications, 2020 Sep 4;11(1):4413
3. Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H, "Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner", Communications Biology, 2021 Jun 2;4(1)656